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VEGF SIGNALING INTEGRATES THE UPR MACHINERY OF THE ENDOPLASMIC RETICULUM IN PHYSIOLOGIC RESPONSES SUCH AS ANGIOGENESIS

Apr 23, 2014

Researchers at theDepartment of Biomedical Research IMBB Ioannina revealed that growth factor signaling in cells integrates the response mechanism to the presence of unfolded proteins (Unfolded Protein Response, UPR) in the endoplasmic reticulum (ER). This study shows that ER plays an important role in normal cell functions, such as signaling by growth factors, and is not limited to the adaptation of the cell to stress.

On April 17th, Molecular Cell, a highly recognized scientific journal, published the article Karali et al. by the team of Prof. Fotsis (http://www.cell.com/molecular-cell/) with experimental results generated in the Ioannina-located Division of Biomedical Research of Institute of Molecular Biology and Biotechnology, FORTH.

Evdoxia Karali, Sofia Bellou, Dimitris Stellas, Apostolos Klinakis, Carol Murphy, and Theodore Fotsis. VEGF Signals through ATF6 and PERK to Promote Endothelial Cell Survival and Angiogenesis in the Absence of ER Stress. Molecular Cell2014, http://dx.doi.org/10.1016/j.molcel.2014.03.022

See the Press Release (pdf)