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New scientific discovery by researchers at FORTH DNA damage triggers metabolic reprogramming, leading to aging
New scientific discovery by researchers at FORTH DNA damage triggers metabolic reprogramming, leading to aging
Jan 07, 2020
Inborn defects in DNA repair mechanisms are associated with cancer, aging but also complex metabolic and endocrine disorders. Integrity of the genome is critical for normal cellular function but the DNA is continually challenged by intrinsic and extrinsic genotoxic factors. To counteract DNA damage, cells have evolved DNA repair mechanisms ensuring that the genome remains functionally intact and is faithfully transmitted to progeny. Nucleotide excision repair (NER) is a major DNA repair mechanism that cells employ to remove a wide class of bulky, DNA-distorting lesions from the genome. The importance of NER defects in man is illustrated by rare syndromes that either show increased cancer predisposition or dramatic features of accelerated aging, including depletion of fat depots. However, with the exception of cancer and aging, the links between defects in NER and the rapid onset of developmental defects in humans are not well understood.
The Achilles’ heel of malaria vectors: novel insecticide resistance mechanisms expressed in their legs
The Achilles’ heel of malaria vectors: novel insecticide resistance mechanisms expressed in their legs
Dec 31, 2019
Malaria has halved since 2000 (approximately 500,000 lives saved every year), with 80% of the reduction attributable to the use of insecticides. However, insecticide resistance is at a critical tipping point in public health, with some mosquito populations showing resistance to all insecticides and the strength and impact of this resistance is escalating every year. As a result, for the first time after many years, malaria cases were increased in several places after 2015, despite the far more intense use of insecticides.
Prestigious ERC Consolidator Grant awarded to FORTH Researcher Dr. Giorgos Chamilos
Prestigious ERC Consolidator Grant awarded to FORTH Researcher Dr. Giorgos Chamilos
Dec 10, 2019
Giorgos Chamilos, Researcher at the Institute of Molecular Biology and Biotechnology of the Foundation for Research and Technology – Hellas (FORTH) and Associate Professor at School of Medicine, University of Crete, is awarded a Consolidator Grant from the European Research Council (ERC).
Professor George A. Garinis awarded with the Friedrich Wilhelm Bessel Research Award
Professor George A. Garinis awarded with the Friedrich Wilhelm Bessel Research Award
Nov 26, 2019
George A, Garinis, Professor of Genetics at the department of Biology at the University of Crete and affiliated group leader at the Institute of Molecular Biology and Biotechnology (IMBB) of the Foundation of Research and Technology Hellas (FORTH), is the recipient of the prestigious Friedrich Wilhelm Bessel International Research Award of the Alexander von Humboldt Foundation. The official award ceremony will take place in Bamberg, Germany in March 2020.