A new icy planet detected in our nearest exoplanetary systemStrong indications for the existence of a second planet in orbit around Proxima Centauri, the nearest star to the Sun, have been recently unveiled by an international team of scientists.

New scientific discovery by researchers at FORTH DNA damage triggers metabolic reprogramming, leading to aging Inborn defects in DNA repair mechanisms are associated with cancer, aging but also complex metabolic and endocrine disorders. Integrity of the genome is critical for normal cellular function but the DNA is continually challenged by intrinsic and extrinsic genotoxic factors. To counteract DNA damage, cells have evolved DNA repair mechanisms ensuring that the genome remains functionally intact and is faithfully transmitted to progeny. Nucleotide excision repair (NER) is a major DNA repair mechanism that cells employ to remove a wide class of bulky, DNA-distorting lesions from the genome. The importance of NER defects in man is illustrated by rare syndromes that either show increased cancer predisposition or dramatic features of accelerated aging, including depletion of fat depots. However, with the exception of cancer and aging, the links between defects in NER and the rapid onset of developmental defects in humans are not well understood.

The Achilles’ heel of malaria vectors: novel insecticide resistance mechanisms expressed in their legsMalaria has halved since 2000 (approximately 500,000 lives saved every year), with 80% of the reduction attributable to the use of insecticides. However, insecticide resistance is at a critical tipping point in public health, with some mosquito populations showing resistance to all insecticides and the strength and impact of this resistance is escalating every year. As a result, for the first time after many years, malaria cases were increased in several places after 2015, despite the far more intense use of insecticides.

Prestigious ERC Consolidator Grant awarded to FORTH Researcher Dr. Giorgos Chamilos Giorgos Chamilos, Researcher at the Institute of Molecular Biology and Biotechnology of the Foundation for Research and Technology – Hellas (FORTH) and Associate Professor at School of Medicine, University of Crete, is awarded a Consolidator Grant from the European Research Council (ERC).