IMBB researchers uncover a novel mechanism that controls longevity by coordinating mitochondrial biogenesis and turnover in the cell, during ageing
Research at the Institute of Molecular Biology and Biotechnology, published today in the premier international scientific journal Nature, reveals an intricate molecular mechanism that coordinates the biogenesis and selective elimination of mitochondria, to regulate cellular energy homeostasis during ageing.
George Garinis, a Professor at the Department of Biology, University of Crete and an affiliated group leader at the Foundation for Research and Technology - Hellas (FORTH), has recently been awarded the prestigious European Research Council (ERC) Consolidator Grant for his research proposal titled "Dissecting the Functional Role of Nucleotide Excision Repair in Mammals-DeFiNER."
A state-of-the art approach to enhance the resolution of non-invasive medical diagnosis techniques is to utilize nano-size materials which are delivered at the regions of interest and allow improved tissue contrast. For such applications, magnetic iron oxides are emerging as promising probes in the diagnosis of various diseases and especially in the area of magnetic resonance imaging (MRI).
VEGF SIGNALING INTEGRATES THE UPR MACHINERY OF THE ENDOPLASMIC RETICULUM IN PHYSIOLOGIC RESPONSES SUCH AS ANGIOGENESIS
Researchers at the Department of Biomedical Research IMBB Ioannina revealed that growth factor signaling in cells integrates the response mechanism to the presence of unfolded proteins (Unfolded Protein Response, UPR) in the endoplasmic reticulum (ER). This study shows that ER plays an important role in normal cell functions, such as signaling by growth factors, and is not limited to the adaptation of the cell to stress.
Phase separation in otherwise chemically homogenous, strongly correlated electron systems is a crucial parameter, leading to fascinating tunable functional properties, such as high-Tc superconductivity in cuprates and giant magnetoresistance in manganites.
A new research programme approved by the ERC: “Accreting binary populations in Nearby Galaxies: Observations and Simulations” (A-BINGOS)
A new distinction for FORTH comes from the European Research Council (ERC) which approved the research program submitted by Dr. Andreas Zezas, researcher of the Astrophysics Group at the Institute of Electronic Structure and LASER (IESL) of FORTH. The approved program is entitled: "Accreting binary populations in Nearby Galaxies: Observations and Simulations" (A-BINGOS), and was submitted in the first ERC "Consolidator Grants" call. The goal of the ERC Consolidator Grants is to "enable already independent excellent researchers to consolidate their own research teams and to develop their most innovative ideas". In this call were approved 312 programs out of 3637 submitted proposals (a success rate of 8.5%). The program A-BINGOS is one of the only 2 programs awarded to Greek Institutions, and the first one to be awarded to a Greek Astrophysicist.
From amputation to regeneration – researchers identify shared features of limb regeneration in crustaceans and vertebrates
Many animals – such as crabs, octopuses and salamanders – have the ability to regenerate parts of their body that are severely injured or amputated. Just as we are able to replace a broken part of our car, these animals can replace lost limbs by new ones with the same form and function. Contrary to cars, animals do not possess spare parts and cannot suspend their functions in order to be repaired; they generate their new limbs in situ, while going about in their normal lives.
Controlling the propagation of high-intensity light beams as they travel through transparent media is a challenging task, but IESL scientists have now shown that a relatively new type of light beam called a ring-Airy beam can self-focus into intense light bullets that propagate over extended distances. These highly focused, high-intensity ring-Airy beam light bullets offer a very unique level of control that cannot be achieved with equivalent Gaussian beams, making them ideal for a variety of optical applications ranging from precision materials processing and nanosurgery to attosecond pulse drivers.
Thousands of proteins are produced inside our cells. More than a third of these proteins can fulfill their function only after migrating to the outside of the cell, becoming anchored to the cell membrane or being targeted to specific subcellular compartments. How cells regulate trafficking of their proteins is a fundamental problem in biology andis essential for life. Examples of migrating proteins are insulin (whose absence leads to diabetes), antibodies (that combat infections), membrane channels (essential amongst other for neuronal cell function) and toxin-proteins secreted by pathogenic microorganisms.
IMBB researchers reveal that DNA damage triggers a chronic auto-inflammatory response leading to fat depletion
Research carried out at the Institute of Molecular Biology and Biotechnology-FORTH and published today in Cell Metabolism reveals that intrinsic DNA damage triggers a chronic auto-inflammatory response leading to fat depletion.
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